Short answer: 18.015 g of water is 1 mol, which is 6.02214076 × 10²³ molecules and, if it were a gas at STP, 22.414 litres. Every stoichiometry problem starts from this conversion.
Why moles exist
Reaction equations count particles; balances weigh grams. A mole is a fixed count chosen so the arithmetic lines up: the molar mass in g/mol is numerically the same as the atomic mass in u, so the two units cancel exactly and no conversion factor is invented.
Worked example
5.85 g of sodium chloride (M = 58.44 g/mol) is 0.1001 mol, which is 6.03 × 10²² formula units. In 250 mL of water that is a 0.400 mol/L solution — the same concentration the molarity calculator reports from the other direction.